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Tirzepatide has been found to improve markers of -cell function, such as increased HOMA2-B indices and reduced proinsulin levels, proinsulin/C-peptide ratios, and proinsulin/insulin ratios, indicating better insulin processing and reduced -cell stress [22,23]

Waning of the effect is possible after three months of therapy

Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro