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The effects of GLP-1R activation are mediated by the activation of downstream signals that increase cellular cyclic AMP (cAMP) levels [33,34,35]

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci 58(20):17771784

Lactate is then exported to the microenvironment and transported into cancer cells, where it induces the lactylation of small nuclear ribonucleoprotein polypeptide A, thereby regulating splicing of AR and generating AR splicing variant 7 (ARV7) (34)