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Roth JA, Swisher SG , Meyn RE

Health Food Stores Specialty health stores often carry a wide range of supplements, including herbal extracts, protein powders, and omega-3 fatty acids

have demonstrated that calorie restriction, but not metformin (in the diet 300 mg/kg/day), extended lifespan in male Fisher-344 rats, leading to the conclusion that metformin is not a calorie restriction mimetic (CRM) (78) (see Table 1 for a summary)