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Here, we present compelling results demonstrating a functional connection between altered TrkB signalling in iSPNs and changes in glutathione metabolism, particularly the enzyme GSTO2, at the pre-symptomatic stage, causing an early increase in DA followed by progressive degeneration and the onset of hyperkinetic symptoms

Essa combinao estratgica rene dois compostos com mecanismos complementares, atuando de forma localizada e sistmica em estudos de regenerao tecidual

In particular, reduced glutathione , often referred to in its fully active form, is the one doing all the heavy lifting

These findings add evidence to the ability of curcumin to increase glutathione levels and protect cells from further oxidative stress and damage