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RNA-based medical technology has paved the way for relatively quick vaccine development following the COVID-19 pandemic
contraindicated in pregnancy due to teratogenicity risk Naltrexone-bupropion (Contrave): Opioid antagonist and antidepressant combination producing 5-6% weight loss
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Phase 2 results at 48 weeks (Jastreboff et al., NEJM 2023): Phase 3 TRIUMPH-4 at 68 weeks (Lilly Press Release, Dec 2025): The 12 mg dose produced 28.7% body weight loss, an average of 71.2 lbs from a 248.5 lb baseline
Knowing this, it is easy to understand why people who are diagnosed with obesity can benefit from GLP-1 medications
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