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MAT1A encodes two liver-specific MAT isoenzymes, such as MATI (MAT1A homo-tetramer) and MATIII (MAT1A homo-dimer), that catalyze the transfer of an adenosyl group of adenosine triphosphate (ATP) to Met to produce SAMe and tripolyphosphate ( MAT2A , and is expressed in all tissues, such as the liver, albeit to a smaller extent ( Figure 1 SAMe serves mainly as a methyl donor in the cell and transfers its methyl group to substrates such as nucleic acids, proteins, lipids, and secondary metabolites with the formation of S-adenosylhomocysteine (SAH, which is also abbreviated as AdoHcy), via transmethylation ( 2

Thus, in reality, its competence to exist in distinct redox states makes it highly valuable in the perseverance and regulation of the cellular thiol-redox status in stressed plants [158]

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