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Mitsuishi et al., 2012)

doi: 10.1073/pnas.86.12.4455 80

Activated MC3R/MC4R are reported in the literature to couple to G s , stimulating adenylyl cyclase and elevating intracellular cAMP, which engages PKA-mediated downstream signalling

Other conditions in which neurogenic inflammation may be implicated include irritable bowel syndrome, vulvodynia, migraines, and fibromyalgia, conditions that frequently overlap with IC/BPS