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This vascular dysfunction may cause the development of cerebral amyloid angiopathy and may contribute to the neurodegenerative processes observed in AD [17]

[10] The pharmacokinetic profile of melatonin demonstrates rapid absorption with peak plasma concentrations typically achieved within 30 to 120 minutes after oral administration, though considerable inter-individual variability exists

Staying hydrated and eating balanced meals even when appetite is low helps minimize discomfort during the adjustment phase

Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar purkinje cells