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The current clinical evidence of intravenous glutathione for skin lightening is limited to a single study with a dubious study design and apparently flawed analysis of results, casting doubt on the drug's efficacy and reported adverse effects, with no evidence to prove its efficacy.There was only one placebo-controlled study on intravenous glutathione showing 37.5% response versus 18.7% placebo, and IV glutathione is contraindicated due to lack of efficacy and side effects

10.1095/biolreprod.102.009167

Vesicular and nanocarriers The drug-carrying vesicles in transdermal delivery including liposomes and nanoparticles are one of the most promising methods which ease skin penetration as it improves fluidizing the skin lipids, the drug portioning into the skin, and drug solubilization into the formulations [289, 290]

Clinical data demonstrates that most gastrointestinal symptoms are short-lived: Nausea: Median duration of 8 days per episode, with most occurrences during the first 4-8 weeks of therapy or immediately following dose increases