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To mitigate the buildup of these potentially lipotoxic intermediates, a portion of the acyl groups is transferred to carnitine, forming acylcarnitines that accumulate intracellularly [120]

Abbreviations ASCA anti- Saccharomyces cerevisiae antibody FGID functional gastrointestinal disorders GF germ-free IEB intestinal epithelial barrier IBD inflammatory bowel disease IBS irritable bowel syndrome IBS-C constipation-predominant irritable bowel syndrome IBS-D diarrhea-predominant irritable bowel syndrome IBS-M irritable bowel syndrome with mixed bowel habit LPS lipopolysaccharides SCFA short-chain fatty acids

Sulovic L, Sulovic V, Zivkovic Z et al (2019) Assessment of left ventricular diastolic function in children undergoing hemodialysis

Wegovy commonly causes nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation