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References Anitua, E., Pino, A., Martinez, H., & Orive, G

conducted an RCT to investigate the prophylactic effects of lycopene against indomethacin-induced gastric ulcer in rats (Boyacioglu et al., 2016).The results showed that pre-administration of lycopene could protect against DNA damage induced by indomethacin, possibly by improving the superoxide dismutase (SOD) activity, glutathione (GSH) level and decreasing catalse (CAT) activity, malondialdehyde (MDA) level and myeloperoxidase (MPO) activity, thus exerting its antioxidative effects

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Studies which integrate the effects of HGF/Met signaling on the tumor microenvironment will provide a more complete understanding of the therapeutic value of targeting HGF/Met in HNSCC