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151 Dopaminergic neurons originating in the VTA project to the NAcc, amygdala, hippocampus, and prefrontal cortex, while those from the substantia nigra project to the dorsal striatum

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Keywords: Tirzepatide, GLP-1, Glucose-dependent insulinotropic peptide, Cardiovascular risk factors INTRODUCTION Tirzepatide is a synthetic peptide composed of 39 amino acids, which functions as a dual receptor agonist (RA) binding both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and this unique mechanism of action resulted in the nickname twincretin. The structure of tirzepatide is based on that of the native GIP with the addition of a 20-carbon fatty diacid moiety, which increases its half-life to 5 days allowing for once-weekly administration

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