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While NAC has been studied for renal protection (contrast-induced nephropathy), dosing adjustments may be necessary in severe renal impairment, and monitoring is advisable [67][68]

This albumin binding dramatically extends the peptides half-life from minutes to approximately 68 days, enabling once-weekly dosing [2]

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Dysbiosis, through the lack of appropriate immunoregulatory and barrier factors, such as, e.g., short-chain fatty acids, causes inappropriate activation of the immune system, resulting in epithelial inflammation, epithelial barrier damage and disease development [55, 57,58,59,60,61]