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The key regulatory milestones: FDA Breakthrough Therapy designation for MASH (September 2024) EMA PRIME designation for MASH (November 2023) China NMPA Breakthrough designation (June 2024) Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) fully enrolled, results expected H1 of this year Estimated FDA filing: Late this year at the earliest Estimated FDA approval: Possibly next year, depending on Phase 3 results If Phase 3 results confirm Phase 2 findings, survodutide could reach the market within the next 12-24 months

Phosphorus treatment should be based on actual kidney status Serum phosphorus, kidney function, diet, parathyroid hormone, vitamin D and overall mineral status should guide restriction or binding strategies

Following an additional 1 h of stirring at 25 C, Ru(II)-OH (50 mg) was introduced into the reaction system

Enhancement of Memory and Learning Dihexa has shown significant potential in improving memory and learning abilities