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The R2R3-MYB gene family in Arabidopsis thaliana

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It is naturally created in the liver and participates in various physiological functions, including: Detoxification: The removal of toxins and heavy metals from the body

This dysregulation is driven by environmental factors such as cigarette smoke (CS) and amplified by dysregulated expression of molecules including prostaglandin E synthase (PTGES), Hedgehog-interacting protein (HHIP), and hypoxia-inducible factor-1 (HIF-1)forming a vicious cycle of environmental damagemetabolic reprogrammingpathological progression. Aberrant glycolysis in COPD patients serves as a critical metabolic basis for airway remodeling and persistent inflammation