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This study was approved by the Tufts University Health Sciences Investigational Review Board

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A DSM study from the human nutrition and health department (59) describes hydroxytyrosol as the most powerful anti-inflammatory compound among polyphenols of olive oil, showing effective inhibition in the production of NO and PGE2, decreasing secretion of cytokines (IL-1, IL-1, IL-6, IL-12, TNF-) and chemokines (CXCL10/IP-10, CCL2/MPC-1) and reducing gene expression of iNOS, IL-1, CXCL10/IP-10, MIP-1, matrix metaloproteinase-9, and prostaglandin E2 synthase (PGES)

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