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Despite these findings, the relationship between baseline adiposity measures, semaglutide-induced weight loss patterns, and cardiovascular outcomes remained undefined. To address this, the investigators conducted a prespecified analysis of the SELECT trial examining the relationships between baseline adiposity measures, treatment-induced adiposity changes, and subsequent MACE risk

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Extracellular flux analysis Bioenergetic parameters were determined using the XF e 96 Extracellular Flux Analyzer (Seahorse Bioscience, North Billerica, MA)