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Research shows that in some people with obesity, the actions or effects of their GLP-1 hormone may be impaired, even in those with normal blood sugar regulation

doi: 10.1007/s11745-006-5033-6

6.6 Traditional Chinese medicine interventions Traditional Chinese medicine (TCM) approaches have shown preliminary promise in modulating the gut-brain axis, though the majority of supporting evidence derives from rodent CUMS models, and high-quality randomized controlled trials in humans with validated constipation-depression comorbidity diagnoses are largely absent

The amylin pathway regulates satiety through different brain regions and different molecular cascades