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These conformational changes are stabilized by additional noncovalent interactions involving the conserved residues, such as the Arg121 making hydrogen bonds with Asp67 to further strengthen the pi-cation interactions involving Trp72, Arg102, and Trp110 (see Figure 4 inset 2)

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As you refine your approach, keep expectations realistic and focus on the small edges you can control: timing your exits, pacing your bet sizing, and recognizing when a boards texture favors another spin