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Contrave is not appropriate for patients with seizure disorders (bupropion lowers the seizure threshold), eating disorders such as bulimia or anorexia, current opioid use or opioid dependence (naltrexone blocks opioid receptors), uncontrolled hypertension, patients taking MAO inhibitors, or women who are pregnant or planning to become pregnant

Within three days, the company saw its share price plunge 27% after delivering disappointing 2026 guidance, only to be blindsided a day later by telehealth platform HIMS launching a $49 Wegovy pill copy. For a brief moment, it looked as if regulatory arbitrage might permanently erode one of the most valuable moats in global pharma

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This binding triggers a cascade of effects: delayed gastric emptying, reduced glucagon secretion, enhanced insulin sensitivity, and most importantly for weight loss, decreased food intake through central appetite suppression (Wilding et al., NEJM, 2021)