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The human albumin variants were expressed in a serum-free transient Expi293 expression system, and all were secreted at comparable quantities to that of WT albumin (2546 mg/L) (Supplementary Fig

Critically, FOXO4-DRI treatment had no measurable effect on cell viability of non-senescent cells

GSTs were shown to catalyze the conjugation between various xenobiotics with electrophilic centers (Figure 1) and the nucleophilic GSH, thus tagging the xenobiotic for vacuolar sequestration (Martinoia et al., 1993)

To determine whether the improved PK properties of the QMP-engineered fusions would translate into enhanced efficacy, we repeated the GTT in human FcRn Tg32 mice