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However, limitations such as phytoconstituent leaching, instability, manufacturing challenges, high production costs, and commercialization hurdles need to be addressed by researchers in the future [101]

A similar paradigm is emerging for tinnitus, advocating for the rational combination of agents with complementary mechanisms, potentially integrated with non-pharmacological interventions

Reactive oxygen species are required for 5-HT-induced transactivation of neuronal platelet-derived growth factor and TrkB receptors, but not for ERK1/2 activation

10.1073/pnas.1902452116 204 Wiener-MegnaziZ.VardiL.LissakA.ShnizerS.ReznickA