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During semaglutide therapy, hepatic stress increases as the body mobilizes stored fat and processes medication byproducts

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75 While standard melatonin supplements rapidly increase blood melatonin levels and can shorten the time needed to fall asleep, newer extended-release formulations have been found to sustain higher melatonin levels through the night in healthy individuals and hold promise for their potential to better maintain sleep through the night

These observations hint at the theory that the increase in both cortical and total BMC may potentially stem from improved bone growth leading to expanded bone dimensions, with the volumetric BMD staying consistent