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In clinical trials, diarrhea is a common side effect, occurring in approximately 30% of patients taking Wegovy (semaglutide 2.4 mg) and 19-23% of patients taking Zepbound (tirzepatide), according to FDA prescribing information

4,5 In developed countries, new classes of organ-protective glucose-lowering drugs, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i), have now become central to the treatment of T2D

According to more recent studies, these drugs can have very serious gastrointestinal side effects, including inflammation in the pancreas and obstructions of the digestive system

Direct Drug Effect: While less understood, the direct pharmacological action of Ozempic on GLP-1 receptors in the central nervous system may also contribute to feelings of fatigue