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With the antioxidant system overwhelmed by lingering ROS, the cardiovascular and nervous systems remain in a state of high alert, driving the unpredictable symptoms that make patients wonder, "Do Long COVID symptoms come and go?" Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by profound energy deficits and post-exertional malaise (PEM), symptoms directly linked to mitochondrial dysfunction

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Medved I, Brown MJ, Bjorksten AR: N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals

doi:10.1016/S0140-6736(24)00194-3 Marso SP, Bain SC, Consoli A, et al