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Description

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Researchers observed that upon binding the IRR, ARA-290 initiates signaling through JAK2 and downstream pathways including STAT3 and NF-B modulation, distinct from the STAT5-dominant signaling of classical EPO receptor activation

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Echocardiography Echocardiography (2D) was performed in all animals 24 h and 48 h after isoprenaline (75 and 150 mg/kg s.c

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