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The Angelica sinensis polysaccharide (ASP), one of the primary active compounds derived from Angelica sinensis (Hou et al., 2021), has been found to significantly reduce the duration of forced swimming and immobility in mice with hanging tails at a dosage of 40 mg/kg (Zhang et al., 2019) through ovarian removal combined with CUS, aiming to explore the correlation between the antidepressant effect of sulfated pachymaran (SP) and AMPA receptors (Zhang et al., 2019)