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Choosing the Right Formulation Different magnesium salts have varying elemental magnesium content and bioavailability: Magnesium citrate : Well absorbed, commonly used, may have laxative effect Magnesium glycinate : Highly bioavailable, generally well tolerated, less likely to cause diarrhoea Magnesium oxide : High elemental magnesium content but lower bioavailability, more likely to cause gastrointestinal effects Magnesium chloride : Good absorption, available in various forms Practical Considerations For long-term supplementation, consider starting with a lower dose and gradually increasing to assess tolerance

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Their specific mechanisms of action can complement small molecule drugs or other biologics to achieve improved therapeutic outcomes