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Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Kober LV, et al

Due to its effects on blood pressuretypically a transient increase of 6 mmHg in systolic blood pressure and 3 mmHg in diastolic blood pressurebremelanotide is considered contraindicated for individuals with uncontrolled hypertension or cardiovascular disease

Manufactured in Europe under GMP (Good Manufacturing Practice) and ISO 22000

The role of vitamin B12 and 5-methyl-THF in the conversion of homocysteine to methionine also can have a significant impact on the ability of cells to regenerate the needed active pool of THF derivatives and as such represents the physiologically most significant reaction involving folate