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Most Common Reaction Temporary pain, redness, tenderness, or swelling at the injection site Other Reported Symptoms Headache, flushing, dizziness, itching, sleepiness, or restlessness Administration Typically administered subcutaneously when prescribed that way Medical Supervision Dosing and treatment duration should be determined by a qualified provider Not Every Symptom Has the Same Meaning A small area of temporary redness after an injection is different from redness that spreads, becomes increasingly painful, feels warm, produces drainage, or occurs with fever

VPA is one of the important medications for migraine that could change the DNA methylation pattern through the inhabitation of the histone deacetylase and gamma-aminobutyric acid (GABA)-degrading enzymes (70)