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researchers should always refer to the CoA for the specific lot in hand

However, participation involves: Strict eligibility screening Ongoing monitoring Possible placebo allocation Defined study duration Clinical trials are research studies, not guaranteed treatment pathways

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Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025