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GLP-1RAs have been shown to enhance endothelial function by modulating the expression of genes involved in endothelial apoptosis, angiogenesis, inflammation and thrombosis, specifically by upregulating eNOS and promoting the expression of angiogenesis-related genes, as observed for Ex-4 (133)

doi: 10.1073/pnas.1603244113 47 WenzelSETyurinaYYZhaoJSt CroixCMDarHHMaoGet al

This combination can create conditions that make stone formation more likely

Lee J, Hlaing SP, Cao J, Hasan N, Ahn HJ, Song KW, Yoo JW (2019) In situ hydrogel-forming/nitric oxide-releasing wound dressing for enhanced antibacterial activity and healing in mice with infected wounds