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Since Sikiric et al 47 firstly demonstrated that NO generation in gastric mucosa contributes to the anti-ulcer effect of BPC 157 in gastric lesion, subsequently, several reports analyzed the role of NO modulation in the healing effect of BPC 157 in different tissue injuries by using NO-synthase-blockade L-NAME or NO-system overstimulation L-arginine

However, penicillamine, a copper chelator used in Wilson's Disease, has been reported to, at times, both induce psychosis or reverse psychosis

In contrast, polymeric nanoparticles offer safer storage solutions and greater design versatility [123]