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The respective ligand was modeled into this density using pre-existing monomers in the CCP4 library for 1 , E-64c and E-64d and a custom ligand built using Coots ligand builder for (2 S ,3 S )- t -ES- a9 - b7 (ref

10.1021/acs.jpcb.5b12618 101 TopalianS

The experimental approaches outlined in these application notes support several key research applications in cardiovascular drug discovery and nutraceutical development: Recent advances in in vitro atherosclerosis modeling , including sophisticated 3D systems, tissue-engineered blood vessels, and vessel-on-a-chip technologies, offer enhanced physiological context for future this compound research [1]