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Furthermore, the level of nuclear GSTP-S184D was higher than GSTP (WT) after LPS treatment (Figures 5B,C)

So because B12 is water soluble, there is no toxicity

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Since rapamycin treatment inhibits the alteration of PIP 3 and PTEN levels under insulin-resistant conditions, it is believed that the mTORC1 is involved in negatively regulating the IRS-1/PI3K/AKT signaling cascade downstream of the insulin receptor