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[1] [2] These biologic medications require specific storage conditions to maintain their stability, efficacy, and safety

N Engl J Med 375:311322 Drucker DJ (2005) Biologic actions and therapeutic potential of the proglucagon-derived peptides

Glia 67 , 10471061 (2019)

[43] Here's a simple diagram of berberine's digestive process: Berberine (gut) dihydroberberine (intestine) berberine (bloodstream) As it turns out, that first conversion step is a bottleneck in this entire process