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Potential rebound: Abrupt discontinuation, even from low doses, may cause appetite rebound and metabolic slowdown

For GIPR whose ECL1 was loosely compacted by peptide 20, three residues (Y13 P -L14 P -D15 P ) strengthened the peptide-binding interface by forming a hydrogen bond with F127 1.29b and a salt bridge with R289 ECL2 , significantly stronger than that observed in GLP-1R and GCGR

Staying hydrated between meals (not during meals) helps manage constipation without increasing mealtime nausea

Dietary adjustmentsincluding reduced fat intake, increased soluble fiber, and smaller meal portionscan significantly ease symptoms