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48 These results suggest that prolonged CR may influence bone metabolism through mechanisms distinct from those observed in short-term interventions, highlighting the need for further investigation

GIP : Enhances glucose-dependent insulin secretion and may improve adipose insulin sensitivityadding satiety and glycemic benefits with potentially better GI tolerability in some patients

Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor

It is involved in both specific and nonspecific immune responses: Stimulates phagocytosis and chemotaxis of macrophages and neutrophils Boosts the proliferation and activity of T lymphocytes Stimulates the production of antibodies IgG and IgM Whenever the immune system is activated, such as in case of disease or vaccination, the need of nutrients, including selenium, increases, and an extra supplementation may be advised