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This duration-dependent relationship held up specifically in cardiovascular outcome trials, where the odds ratio reached 2.18 (95% CI: 1.36-3.49)

The pineal gland contributes to circadian timing through the synthesis and release of melatonin

doi: 10.1161/JAHA.120.020646, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 133

Cardiac hypertrophy leads to heart failure at the later decompensated stage of the disease process, which is a primary cause of morbidity and mortality