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Interestingly, the decrease of ATP levels was delayed after the disappearance of dehydrogenase activity in 1 mM PAP-CYS treated cells perhaps implying a preservation of ATP levels even after impairment of intramitochondrial dehydrogenases activity for a limited time

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Reduced expression of tyrosine hydroxylase and TPH, biochemical markers of neuronal integrity, was observed after mephedrone administration, along with downregulation of dopamine D2 receptors in the striatum, indicating the presence of damaged nerve endings 48,49

Given that supplements are concentrated versions of the vitamin, its unclear if foods would have the same effect