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Novo Nordisk announced that the FDA accepted a new drug application for a 25 mg oral version of semaglutide (Wegovy) for two new indications: Chronic weight management in adults living with obesity or who are overweight with at least one comorbid condition Reduce the risk of major adverse cardiovascular events (MACE) in adults with obesity or overweight with established cardiovascular disease (CVD)

Reasoning that the enzymes encoded by these genes could be responsible for the utilization of l-carnitine and its conversion to BB (Figure 7C), we used comparative genomics tools to identify 3 other organisms that contain the caiTABCDE gene operon (Supplemental Figure 5), and assessed their ability to consume l-carnitine and produce BB (Figure 8)

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