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M., Atakisi E., Citil M., Kanici A., Merhan O., et al

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Additionally, the phase 2 MOMENTUM clinical trial of pemvidutide (a dual GLP-1/GCG agonist) showed that only 21.9% of WL was attributable to reductions in lean mass at 48 weeks (overall WL 10.315.6% across doses) [64]

Procyanidins can reduce inflammation and regulate fat metabolism by reducing the TLR4/NF-B pathway and increasing the AMPK pathway, and they are associated with a decrease in Akkermansia and Bacteroides and an increase in Bifidobacterium , Blautia , Lachnospiraceae , and Subdoligranulum ( Bacteroidetes / Firmicutes ratio, Ruminococcaceae_UCG-014 and Ruminococcaceae_UCG-005 , and decrease Lachnoclostridium (Zhao et al., 2017)