-lipoic acid (LA), as an antioxidant, has been reported to play an important role in renal protection, but the underlying mechanism remains poorly explored
[10] Anterior pituitary In the anterior pituitary gland, the effects of somatostatin are: Inhibit the release of growth hormone (GH) [11] (thus opposing the effects of growth hormonereleasing hormone (GHRH)) Inhibit the release of thyroid-stimulating hormone (TSH) [12] Inhibit adenylyl cyclase in parietal cells Inhibits the release of prolactin (PRL) Gastrointestinal system Somatostatin is homologous with cortistatin (see somatostatin family) and suppresses the release of gastrointestinal hormones Decreases the rate of gastric emptying, and reduces smooth muscle contractions and blood flow within the intestine [11] Suppresses the release of pancreatic hormones Suppresses the exocrine secretory action of the pancreas Synthetic substitutes Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octapeptide that mimics natural somatostatin pharmacologically, though is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone, and has a much longer half-life (about 90 minutes, compared to 23 minutes for somatostatin)
Yu Y, Ding Y, Wang S, Jiang L
If we have an idea that can both work in diabetes in a much safer way than in insulin, and then also at the same time work in obesity
