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Any ETC-related abnormality may have an adverse impact on OXPHOS and the tricarboxylic acid (TCA) cycle, which is a shared process of carbohydrate, fat, and protein metabolism

Infections have been identified as the most common precipitating factor for developing HE, and the most relevant are spontaneous bacterial peritonitis, respiratory tract infections, and urinary tract infections

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Os D3 insert was amplified with an N-terminal cleavable Strep-tag and a C-terminal 6xHis tag and was cloned in the pIDK donor vector