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Try sipping small amounts frequently rather than drinking large volumes at once, choose room temperature fluids instead of very cold water, and consider electrolyte solutions, herbal teas (ginger or peppermint), clear broths, or water-rich foods like watermelon

Besides intestine and kidney, OCTN2 is expressed in several tissues such as placenta, mammary gland, liver, heart, testis, skeletal muscle, and brain, where it is also expressed at the level of the blood-brain barrier (BBB

The non-specific regulation is hypothesized to involve the inhibition of NF-B activation, cyclooxygenase (COX) and prostaglandin synthesis