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As demonstrated by MP0250 28 , the therapeutic protein's half-lives can be significantly extended by genetically fusing non-HSA-binding DARPins or other therapeutic proteins to albumin-binding DARPins

At an average exposure level 4-fold higher than that of the maximum recommended dose of RYBELSUS, semaglutide does not prolong QTc intervals to any clinically relevant extent

Another oral non-peptide GLP-1 medication, orforglipron, has been approved in the United States for weight management

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