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Therefore, it seems interesting and worthy to review this topic, which has captured the interest of many basic and clinical investigators for many years, and gives the opportunity to present their most recent findings, including development of new medicines, pharmacological tools and new approaches to protect or/and heal GI-tract acute injuries and chronic ulcers

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Traditionally, activated macrophages are classified into two main types: proinflammatory M1 macrophages and anti-inflammatory M2 macrophages