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With both compounds reducing energy intake (tirzepatide through appetite) and mobilizing stored energy (AOD 9604 through lipolysis), the body is working harder to maintain homeostasis

Table 6: Treatment of folate deficiency (adapted from Means 2021) 27 TOP Ongoing Care Ongoing Management Vitamin B 12 Duration of therapy Once a diagnosis of B 12 deficiency due to poor absorption of B 12 has been made, therapy should be maintained lifelong

That dual role is part of why the research base touches so many systems: skin, hair follicles, wound beds, lung, gut, and bone in animal and cell models