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When chemical shifts of apo- and haem-bound forms of PGMRC1 were compared, some amino acid residues close to those which disappeared because of the paramagnetic relaxation effect of haem exhibit notable chemical shifts (Supplementary Fig

2 Materials and methods 2.1 Experimental design The experiment was conducted at the experimental station of the Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), in Braunschweig, Germany in accordance with the German Animal Welfare Act and permitted by the Lower Saxony State Office for Consumer Protection and Food Safety (LAVES, Oldenburg, Germany) (AZ33.19-42502-04-16/2378)

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But here's another important caveat: This study only looked at short-term effects