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Key markers include malondialdehyde (MDA), 8-isoprostane, oxidized glutathione ratio (GSSG/GSH), and catalase levels, which indicate systemic oxidative burden

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The GSH binding site is conserved and is occupied in several virus structures The patch of positive charge within the I site is conserved across a panel of enteroviruses (note strict conservation in VP1 of R216 and R229 and the presence of either K or R at 233 in Fig